Schoppekarl schrieb am 23.08.2021 16:03:
https://pubmed.ncbi.nlm.nih.gov/34384810/
....Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence
Das steht may. Es kann also auch anders sein.
“In conclusion, ADE may occur in people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors) and then exposed to a Delta variant. Although this potential risk has been cleverly anticipated before the massive use of Covid-19 vaccines, the ability of SARS-CoV-2 antibodies to mediate infection enhancement in vivo has never beend formally demonstrated.”
Hier steht ebenfalls may. Zudem fehlt da ein Teil:
...has never been formally demonstrated. However, although the results obtained so far have been rather reassuring, to the best of our knowledge ADE of Delta variants has not been specifically assessed. Since our data indicate that Delta variants are especially well recognized by infection enhancing antibodies targeting the NTD, the possibility of ADE should be further investigated as it may represent a potential risk for mass vaccination during the current Delta variant pandemic. In this respect, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.
Bei der Entwicklung der Impfstoffe gab es halt noch keine Delta-Variante. Gut, man hätte vielleicht mit der Impfstoff-Entwicklung noch länger warten können und diese besser untersuchen können. Aber was wäre, wenn danach sich eine Variante entwickelt hätte, die das Risiko zu ADE in Kombination mit der Impfung erhöht hätte. Es wird ja darauf hingewiesen, dass eine zweite Generation von Impfstoff dies berücksichtigen soll.