Aus 2 bzw 5
Over the 12-month follow-up, the primary outcome occurred in 67 participants (5.3%) assigned influenza vaccine and 91 participants (7.2%) assigned placebo (hazard ratio, 0.72 [95% CI, 0.52–0.99]; P=0.040). Rates of all-cause death were 2.9% and 4.9% (hazard ratio, 0.59 [95% CI, 0.39–0.89]; P=0.010), rates of cardiovascular death were 2.7% and 4.5%, (hazard ratio, 0.59 [95% CI, 0.39–0.90]; P=0.014), and rates of MI were 2.0% and 2.4% (hazard ratio, 0.86 [95% CI, 0.50–1.46]; P=0.57) in the influenza vaccine and placebo groups, respectively.
Die Breite der CIs ist nicht so toll.
Aus 4
At a median follow-up duration of 19.5 months, influenza vaccine was associated with a lower risk of all-cause mortality (RR, 0.75; 95% CI, 0.60–0.93 [P=0.01]), cardiovascular mortality (RR, 0.82; 95% CI, 0.80–0.84 [P<0.001]), and major adverse cardiovascular events (RR, 0.87; 95% CI, 0.80–0.94 [P<0.001]) compared with control. The use of the influenza vaccine was not associated with a statistically significant reduction of myocardial infarction (RR, 0.73; 95% CI, 0.49–1.09 [P=0.12]) com- pared with control.
Auch hier keine so tollen CIs, bis auf cardiovascular mortality.
Da aber die all-cause mortality eventuell nicht so toll sinkt, bringt das auch nicht viel.
Ich habe vor kurzem eine andere große Metastudie quergelesen, da wurden über 2200 relevante Studien identifiziert, und bis auf 6 fast alle ausgesondert.
Insgesamt finde ich das nicht so überzeugend.