Andere Frage: Wie passt es zusammen, dass diese Unternehmen große Vaxxin-Fabriken aufbauen, die ja nach erreichen der Herdenimmunität nichts mehr zu produzieren hätten?
Im Ernst? Das ist quasi das was ich und viele andere an Corona feiern, so schlimm es auch ist. Die Vaxxin-Fabriken werden aufgebaut, weil die für die JETZIGE Pandemie gebraucht werden und damit sind die bezahlt. Nach der Pandemie, haben wir überall auf der Welt die Kapazitäten für Peanuts mRNA-Impfungen herzustellen. Das katapultiert die ganze Welt von Null auf Hundert in ein neues Medizinzeitalter.
Zitat:
But its next step could be even bigger. The scope of mRNA vaccines always went beyond any one disease. Like moving from a vacuum tube to a microchip, the technology promises to perform the same task as traditional vaccines, but exponentially faster, and for a fraction of the cost. “You can have an idea in the morning, and a vaccine prototype by evening. The speed is amazing,” says Daniel Anderson, an mRNA therapy researcher at MIT.
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Amesh Adalja, an expert on emerging diseases at the Johns Hopkins Center for Health Security, in Maryland, says mRNA could “make all these applications we were hoping for, pushing for, become part of everyday life.”
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While the world remains focused on the rollout of Covid-19 vaccines, the race for the next generation of mRNA vaccines – targeted at a variety of other diseases – is already exploding. Moderna and BioNTech each have nine candidates in development or early clinical trials. There are at least six mRNA vaccines against flu in the pipeline, and a similar number against HIV. Nipah, Zika, herpes, dengue, hepatitis and malaria have all been announced.
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“Biotech generally doesn’t have as much disruption as the computer tech industry – development times are long, it's heavily regulated. So you can usually see change coming,” says Hartaj Singh, an industry analyst with Oppenheimer & Co. “Covid turned that on its head; mRNA vaccines quickly came out as the big winner. Lots of older vaccine platforms will be gone – replaced – in a few years, or at least greatly diminished.”
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Şahin would go further. “It will be transformative, there's no question. It will be absolutely transformative. Many older vaccine platforms will not survive.” But, he says, the impact will go beyond what we already know. “There are so many more things we can do. This is not just a replacement; we will be coming up with other new medical innovations that wouldn’t otherwise be possible.”
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Moderna has taken to calling mRNA therapies the “software of life”, or an “operating system” for medicine.
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This gives mRNA a massive speed advantage over traditional methods, meaning the flu virus would have less time to mutate before a vaccine arrives. “The lead time to make the vaccine is so much shorter. You could make a huge batch in two weeks. You could even have multiple different flu vaccines across the winter if it changes in real time,” Blakney says.
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Decades of research suggest many likely targets on the influenza virus for such a vaccine, but targeting multiple sites across multiple influenza strains quickly ramps up the complexity and costs for the traditional approach. Not so with mRNA, says Pardi: “We can easily have 12 or 14 targets in a single shot. Four proteins, and their variants, in multiple strains.”
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Suddenly, the scientific timeline for this incredibly ambitious project is compressed by years – decades even, says Cain.
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mRNA factories need just a fraction of the space. From the size of a “football pitch to a front lawn,” one engineer quipped to me. But there’s no reason they couldn’t get even smaller and simpler. “Like fitting on a desktop, the size of a photocopier.
https://www.wired.co.uk/article/mrna-vaccine-revolution-katalin-kariko